This course will help otolaryngologists discuss the emerging role of human papillomavirus (HPV) in head and neck cancer (HNC) and handle the common questions and answers that arise when discussing the diagnosis of HPV-associated head and neck cancer (HNC). The epidemiology, clinic-demographic and prognosis of this unique disease entity will be reviewed. In addition, we will focus on the behavioral questions that arise as the sensitive topics of sexual behaviors, HPV and HNC are discussed with patients and their families. We will contextualize the commonly asked questions regarding risk factors, prognosis, and implications for relationships. This course should provide a framework for these difficult clinical conversations.Learning Objectives: 1. Discuss the unique epidemiologic, clinic-demographic and prognostic implications of HPV-HNC.2. Explain behavioral implications in an evidence-based manner with patients and families, and understand the limitations of our current knowledge.3. Teach other clinicians and members of their multidisciplinary team a framework for the discussion of HPV-HNC.Faculty: Carole Fakhry, MD (Nothing to disclose), Jose P. Zevallos, MD, MPH (Nothing to disclose).