Evidence based algorithm to individualize multimodality treatment of HPV + oropharyngeal carcinoma with the goal of optimization of oncologists and functional outcomes will be discussed. Expert discussion and audience participation will explore individual case scenarios, how to weigh options for treatment, how to involve the patient goals and desires, and how to manage cost of treatment.Learning Objectives: 1. Employ evidence-based management decisions on treatment of Oropharynx earl carcinoma. 2. Summarize disease nuances and their implications for treatment and outcome. 3. Identify deintensification treatment and protocol outcomes.Faculty: Kathryn Van Abel, MD(Nothing to Disclose), Daniel Price, MD(Nothing to Disclose), Eric Moore, MD(Other: AO North America; Salary: Intuitive Surgical; AO North America; Leadership Role: Head and Neck Cancer Alliance).