The management of cutaneous melanoma of the head and neck is undergoing a transformation. Changes in AJCC staging, controversies relating to threshold for sentinel lymph node biopsy and neck dissection, and increasing role of immunotherapy in management of melanoma are all important areas that are dramatically altering diagnostic and therapeutic practice patterns. Otorhinolaryngologists play an important role in management of patients with head and neck cutaneous melanoma, and need to stay up to date on surgical controversies, emerging therapeutics, and combinatorial therapies. This panel discussion will focus on informing otorhinolaryngologists about key updates relating to sentinel lymph node biopsy, approaches to management of cN0 nodal basins upon discovery of positive sentinel nodes for patients with head and neck cutaneous melanoma, the integration of systemic therapy in management of advanced head and neck melanoma, and the nuances of utilizing injectable immunotherapy agents in clinical practice. Additionally, practice pearls and pitfalls relating to setting up a program focused on injectable immunotherapy for otorhinolaryngologists will be described utilizing a case based approach. Audience members will have the opportunity to engage in focused discussion in the areas of panelists' presentations.