Systematic reviews are the most widely cited publication type and have broad implications for patient care, guideline development, research proposals, and health policy formulation. The best clinicians understand how to use "best evidence" from systematic reviews that locate, appraise, and synthesize evidence from primary research. The gold-standard for systematic reviews is set by the Cochrane Collaboration, which publishes the Cochrane Library, but many high-quality non-Cochrane reviews increasingly appear in peer-reviewed journals. Two editors of Cochrane ENT, which produces the ENT reviews for that publication, teach this course. Participants will enhance their clinical practice by learning how to read, interpret, and create a systematic review or meta-analysis.