As Human Papilloma Virus (HPV) associated head and neck cancer became the most common HPV-associated cancer in 2020, otolaryngologists need to know how to discuss this diagnosis with their patients. Patients are reading more about this disease via the internet, and are asking more and more questions based on the information they have learned. Many common topics that patients wished to have addressed include routes of transmission, infidelity, risk of future transmission, partner risk for development of HPV-associated cancers, and ability to participate in future sexual activities. Addressing these questions is essential to providing comprehensive cancer care. In order to be able to adequately answer these questions, otolaryngologists need to be comfortable having conversations about sexual transmission and future sex practices. This panel will help to provide the audience with helpful and evidence based responses to some of the most common questions that HPV positive cancer patients are asking.