Regardless of whether you seek to stay healthy, improve your health, or even reverse chronic disease, transitioning to a diet rich in plant foods can help you achieve your goal. Compelling scientific evidence highlights that the best diet for optimal health is a whole-food, plant-based (WFPB) diet. Whole foods occur naturally and are unrefined (not stripped of nutrients), unprocessed (no added salt, oil, sugar, etc.), or only minimally processed (e.g., cleaned, chopped, frozen). More specifically, a WFPB diet is a type of vegetarian diet that emphasizes eating plants (vegetables, fruits, whole grains, legumes, beans, nuts, and seeds), discourages eating refined carbohydrates (such as white rice, white bread, and pastries) and other foods that have been stripped of their nutrients (extracted oils, fruit juice, many prepared and convenience foods). Obesity, diabetes, heart disease, and high blood pressure, and some cancers are directly related to poor diet, and other lifestyle choices that include inadequate exercise and sleep, stress and burnout, and substance abuse. The food we eat can lead us to disease or to vibrant health and longer life, and this presentation is intended to foster the former.