Recent publications continue to change our daily practice in pediatric otolaryngology, general otolaryngology, and head and neck surgery. Among the half-million articles published each year, only a limited subset have clinical results, study designs, and demonstrated validity which could (or should) change how we practice. Well-intentioned, motivated practitioners may inadvertently miss these key publications, which can be hidden in the vast sea of surrounding manuscripts. It is critical, however, to have awareness of important, actionable, new data to provide optimal, current patient care. This program thus highlights recent publications which substantiate changing clinical practice in children and adults. Topics addressed include ear disease, chronic rhinosinusitis, tonsillectomy, and head and neck masses, among others. The selected publications span the spectrum of daily pediatric and comprehensive otolaryngology practice, as well as otology, rhinology, and other areas. All new publications and data are presented in 2022, including key action items as they relate to existing standards. The panel encompasses the editorial leadership from top-tier otolaryngology journals, as well as leadership from the clinical practice guidelines and consensus statements endorsed by national professional organizations.