When healthcare professionals work with their patients to introduce treatments or medications that are specific to the patient’s needs and discuss with them their lifestyle and choices, then we see what can truly be called “personalized medicine.” It’s not a “one size fits all” approach – it’s meeting each patient where they are, involving them in the decision-making process, and moving forward together to improve health outcomes. Healthcare works best when doctors and patients work together to decide upon the best care for each patient. This practice is called Shared Decision Making, and it’s designed to benefit doctors and patients alike. Shared Decision Making encourages patients and families to take a more central and active role in their care by working with their doctor to participate in the choices surrounding their treatments and medication options. It’s evidence-based and balances risks and results with a patient’s preferences and values. As there are now multiple treatment options for chronic rhinosinusitis with nasal polyps, how should an otolaryngologist decide what is best for a particular patient? We will discuss how to incorporate Shared Decision Making in patients with chronic rhinosinusitis with nasal polyps. In this session, a rhinologist and a comprehensive otolaryngologist will review cases with the audience and discuss how they incorporated Shared Decision Making to truly result in personalized medicine (Targeted Therapies + Shared Decision Making = Personalized Medicine)