Numerous procedures in otolaryngology require either additional tissue transfer or control of a scarring process. There are a number of viable options for tissue engineering or controlled drug delivery of anti-scarring agents to healing wounds. First, tissue-engineering has many potential applications in otolaryngology including pediatric laryngotracheal reconstruction, open rhinoplasty, and tympanoplasty reconstruction. We will discuss several current animal model projects with these procedures using cartilage tissue engineering techniques with a variety of scaffolds including decellularized meniscal cartilage as well as both natural and synthetic scaffolds. We will outline our results as well as our strategies to translate the techniques to human procedures. In addition, we will outline promising techniques for controlled drug delivery in otolaryngology including use of drug-eluting stents and endotracheal tubes to prevent scarring. We will show both basic science research findings as well as translational applications.