Sixty percent of pediatric and adult patients with Cystic Fibrosis (CF) report chronic rhinosinusitis (CRS) symptoms when questioned and endoscopic and radiographic evidence of sinonasal inflammation is nearly universal. Frontal headaches, anosmia, obstruction, discharge, and congestion are all common to the CF population. This panel of pediatric and adult rhinology experts will discuss the evaluation, medical management, imaging indications, surgical options, and long-term care of the pediatric and adult cystic fibrosis patient. New Cystic Fibrosis Otolaryngology Guidelines for Care will be presented and discussed. The introduction of new Cystic Fibrosis Transmembrane Receptor corrector/modulator medical therapy will also be reviewed, outcome studies discussed, and clinical cases showcased.