The National Institutes of Health (NIH) is the largest public funder of biomedical research in the world, investing more than $32 billion a year to enhance life, and reduce illness and disability. Federal grants from the NIH are essential to support research programs and maintain a pipeline of clinician-scientists. Surgeons are distinctively positioned to make meaningful contributions to our understanding of disease and the discovery of innovative therapies. Given their unique perspectives in the diagnosis and treatment of certain pathologies and their direct access to tissue samples, surgeons are suited to perform high quality research. However, the complexity of assembling a grant application and navigating the funding landscape can be a hurdle for early- and mid-career researchers.This session will provide a comprehensive overview of the institutes and centers within the NIH that make grant awards. Attendees will gain an understanding of NIH funding announcements and awards mechanisms and learn how and what to apply for. Attendees will also learn how to identify and foster relationships with Program Officers to determine the right fit for their application into an NIH program. A summary of the types of grant programs supported by the NIH will be provided, with a focus on strategies for securing competitive independent funding for early- and mid-career researchers. Attendees will also learn about the psychology of grant review and how to tackle resubmissions for ultimate success.