Chronic cough is exceptionally common, accounting for up to 3% of ambulatory clinical visits in the US, and with a prevalence of up to 10% globally. Over the last 20 years evidence-based clinical practice guidelines by the American College of Chest Physicians, the European Respiratory Society and others have matured, but challenges to patient care have remained. The greatest barriers to managing patients with chronic cough have been 1) advancing the science of cough, 2) defining gaps in care delivery of best-practice, and 3) understanding the longitudinal journey of the cough patient as a conduit to comparative effectiveness and outcomes research. The last 5 years have seen significant progress in these areas, to include discovery of the P2X3 ion channel in the cough receptor. It’s preeminent role in cough hyper-excitability is a breakthrough that changes chronic cough as a symptom, to a disease in some patients. This program presents new discoveries in basic science, population health, and the most current clinical practice guidelines supporting evidence-based state-of-the-art in evaluating and managing chronic cough patients. Since cough may be an indicator of serious underlying disease, a systematic method at evaluation and management is presented, along with appropriate objective testing. Otolaryngologists play a critical role in these patients due to our interdisciplinary approach to the aerodigestive tract, and mastery of many procedures used to evaluate and treat related conditions. Challenging cases will be presented to demonstrate practical clinical applications. Controversial areas to be discussed include warning signs, decision protocolization, and the introduction of comparative effectiveness for value-based healthcare.