PROGRAM DESCRIPTION: The worldwide incidence of thyroid cancer has increased and generated great debate and study concerning the proper evidence-based management strategies. Despite this increase, there has been no significant increase in advanced, invasive thyroid cancers which continue to represent the primary cause of thyroid cancer specific death. We seek to present an evidence-based management course on advanced, invasive thyroid cancer to address critical issues of diagnosis, preoperative evaluation, management of tracheal and esophageal invasion, recurrent nerve and parathyroid gland management, neck management, and adjuvant surgical procedures relating to this important subset of patients. Illustrative examples of complex patients drawn from a large single-institutional experience in which there is a very active multidisciplinary thyroid center and tumor board will be presented in the context of evidence-based literature to help guide the practitioner in an area less frequently addressed in most contemporary courses. An emphasis will be placed on the importance of the evidence-based multidisciplinary approach to optimize outcomes.OUTCOME OBJECTIVE 1: Recognize the value and strategies of a multidisciplinary approach to optimize outcomes for the management of invasive thyroid cancerOUTCOME OBJECTIVE 2: Recognize surgical strategies to achieve the most complete removal of structural disease and improved postoperative managementOUTCOME OBJECTIVE 3: Recognize targeted therapy advances and their role in the management of invasive thyroid cancerBACKGROUND STATEMENT: This course has been presented for the past 13 years. There has been a tremendous improvement in surgical and targeted molecular strategies in the care of advanced thyroid cancer which many members of the Academy, both in academic and private settings, would want to be updated on.