The management of cutaneous head and neck (HN) melanoma experienced rapid, transformational change over the past few years. This expert lecture provides a contemporary, case-based, concise framework to highlight pertinent changes to your practice. Melanoma work-up and treatment options will be reviewed in an evidence-based fashion. Sentinel node biopsy techniques and pearls will be shared, along with the utility of a completion neck dissection in the context of the recent MSLT-II trial. New advances in immunotherapy to include PD-1 inhibitors and associated clinical trials will be reviewed so that physicians can hold meaningful patient conversations regarding adjuvant treatment options. We will highlight the most important changes we face, which are often the most challenging, in the management decisions for our melanoma patients. Participants will leave this 1-hour course with a clear understanding of 2021 standards of care for cutaneous HN melanoma.