How can we most effectively evaluate patients with dizziness within the confines of modern practice? During this panel, sponsored by the American Otologic Society, experts in vestibular diagnosis will discuss how to integrate best evidence with clinical experience to efficiently formulate an accurate differential diagnosis for any patient with dizziness. Using illustrative cases, we will present the key questions – focused on timing, triggers, and associated symptoms – that elicit the pertinent history and minimize vague reporting. We will debate the merits of clinical questionnaires and the highest yield physical exam elements that warrant incorporation into daily practice. With this diagnostic framework established, we will guide clinicians in determining what tests to order, if any, by defining the specific questions that can and cannot be answered with the current array of audio-vestibular tests, imaging, and other physiologic investigations. We aim to provide approaches that clinicians can readily implement to make correct diagnoses in a timely fashion, thus expediting initiation of therapy and improving patient outcomes.