Significant advances in the application of lasers in head and neck have occurred in the past 3 decades. The use of lasers in pediatric airway disorders has been limited due to lack of standardized laser parameters and limited training opportunities. The goal of the present hands-on lecture is to provide an in-depth review of the use of laser in pediatric airway disorders, familiarizing the attendee with the optimal technique and airway pathology specific parameters while learning the nuances of laser surgery. Hands on exposure of using the CO2 laser especially the use of flexible fiber will help the attendee to gain confidence in using the tool in a clinical setting. Recent advances including the development of ultrapulse mode, and the use of flexible fiber CO2 laser will be discussed. A special emphasis will be made on appropriate parameters for different airway pathologies enabling the attendee to optimize surgical results.