Emerging publications can change our daily practice. Only a limited number of the half-million articles published each year, however, have clinical results, study designs, and demonstrated validity which could or should change how we practice. Even well-intentioned and highly motivated practitioners can inadvertently miss these key publications, which can be hidden in the vast sea of surrounding manuscripts. It is critical, however, to have awareness of important, actionable, new data. This program thus highlights recent publications which substantiate changing clinical practice in children and adults. Topics addressed include ear disease, chronic rhinosinusitis, obstructive sleep apnea, and perioperative medications, among others. The selected publications span the spectrum of pediatric, otologic, rhinologic, and comprehensive practice. New publications and data are presented in 2021, including key action items as they relate to existing standards. The panel encompasses the editorial leadership from top-tier otolaryngology journals, as well as leadership from the clinical practice guidelines and consensus statements endorsed by national professional organizations.