With its diverse etiologies, demographic variability, and the already large and ever-expanding armamentarium of options available for its treatment, unilateral profound hearing loss (single-sided deafness, SSD) becomes a difficult problem for otolaryngologists, audiologists, and advanced practice providers to treat, specifically as it relates to which rehabilitative option is best for their patients. This discussion will review the various management options for SSD in both the adult and pediatric population with a special focus on an evidence-based approach through accumulated data and reported outcomes. Although we will briefly review key elements of the workup necessary for patients with SSD, the primary emphasis will be placed on specific options available to treat. The review will include traditional amplification instruments (i.e., contralateral routing of signal (CROS) hearing aid), bone-conduction osseointegrated devices (including both transcutaneous and percutaneous options), and finally cochlear implantation.