Advances in pathophysiology and treatment have allowed for greater refinement in the medical and surgical management of chronic rhinosinusitis (CRS). Given the rapidly evolving and dynamic nature of the literature, the otolaryngologist needs to be up to date on the latest evidence and clinical guidelines. This course will provide a framework for interpreting and applying evidence-based medicine (EBM) and evidence-based guidelines. The instructors will summarize current EBM recommendations and the underlying research for fundamental aspects of medical and surgical treatment of CRS. This evidence-based approach will help the clinician understand the current guidelines and recommendations and allow them to interpret new evidence as it is released. We will use a case-based approach to pose management questions from actual cases and then address the literature supporting management decisions.