Laryngeal leukoplakia is a common cause of hoarseness, and the differential diagnosis is vast. This presentation will attempt to provide a framework for workup of laryngeal leukoplakia. The panel, presented by 4 fellowship trained laryngologists, is meant to discuss some of the more challenging cases in which it is difficult to distinguish between infectious and neoplastic etiologies and when repeat biopsy versus a more definitive resection is appropriate.