This course will provide a comprehensive, case-based, and evidence-based review of globus pharyngeus. Potential etiologies of this condition will be emphasized, so that participants can broaden their differential diagnosis of globus pharyngeus beyond reflux alone. Approaches to reflux diagnosis and treatment will be evaluated. Additional considerations of mucosal dryness, sinonasal inflammation, cricopharyngeal hypertonicity / esophageal dysmotility, sensory neuropathy / hypersensitivity, and globus hystericus will also be discussed. Therapeutic and diagnostic approaches to each etiology will be presented, generating a treatment algorithm for this frustrating condition that can provide patients and physicians a pathway to increased satisfaction.