Hearing loss is one of the most common conditions encountered by the practicing otolaryngologist. While treatment, to date, has been mainly supportive (via hearing aids) or rehabilitative (via cochlear implants) a promise for novel therapeutics seems to be now closer than ever. This expert series is designed to review the present knowledge and state of the art research in Otology and Neurotology. We focus our lectures on advances in (a) genetics of hearing loss, gene delivery, and gene therapy; (b) approaches for hearing preservation and restoration including pharmaceutical interventions; and (c) new fronts and understandings of inner ear trauma and its treatments. The program does not require prior knowledge in basic science research and is designed to offer providers sufficient knowledge to understand the current state of research, appreciate translational research on the topic, and engage in conversation with their patients about the future of therapeutics.